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Studies indicate that the aggregation of -synuclein might be responsible for neuronal death in PD

In one study, GSH was administered intravenously to patients with advanced neoplastic disease, in two divided doses of 2,500 mg, shortly before and after doses of cyclophosphamide

Besides the presently reported decreased PST activities, blood hyperserotonemia was also reported to result from increased SERT activity due: (i) to the rare Ala56 ASD-associated gain-of-function mutation in the SLC6A4 gene found in some ASD patients 13 which altered the communication and social domains in knock-in mice 85 or (ii) to a variant in the promoter of the ITGB3 gene 86 which encodes the -chain of the platelet integrin IIb 3 known to interact physically with SERT to promote its externalization and transport activity 87

Naksuriya O, Okonogi S, Schiffelers RM, Hennink WE

Yes, kojic acid effectively removes tan by inhibiting the enzyme tyrosinase, which prevents the production of excess melanin caused by sun exposure