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Subsequently, Na+/Cl+ ion pairs were systematically added to attain a physiological NaCl concentration, emulating intracellular ionic strength conditions 54

This was further substantiated by the observation that inhibiting heightened GJ function with a GJ inhibitor in mice effectively diminished APAP toxicity, which correlated with reduced levels of oxidative stress in hepatocytes

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2009272) and stored at 4C for 1 h

Some of these GSTs are overexpressed in cancer cells 11, 12 , suggesting that tumors could be selectively vulnerable and be targeted with prodrugs activated by the overexpressed enzyme