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Goetz CG, Stebbins GT, Chung KA, Nicholas AP, Hauser RA, Merkitch D, Stacy MA

In gastric cancer after gastrectomy (which removes the gastric parietal cells and, thus, the source of intrinsic factor needed for normal vitamin B12 absorption), supplementation with vitamin B12 can prevent the development of vitamin deficiency (17)

In mitochondria, THF is imported via a mitochondrial folate transporter and converted into 5,10-methylene-THF by serine hydroxymethyltransferase 2 (SHMT2), which oxidizes serine to glycine while transferring a one-carbon unit to THF [15]

They found that ASAH2 inhibition in colorectal cancer cells leads to decreased GSK3 phosphorylation and activation of AKT, a critical cell growth target

In addition, due to variability in the combinations of vasoactive drugs used, noradrenaline-equivalents (NAE) were calculated for each patient to estimate total vasopressor use in mcg/kg/min