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Description

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The reduced expression of GR in limbic regions, associated with FKBP51 dysregulation and hormonal variations of the female reproductive cycle, favors the establishment of a state of resistance to glucocorticoids, resulting in prolonged exposure to glucocorticoids and low-grade inflammation, which supports the higher prevalence and vulnerability of women to the development and maintenance of MDD (Palumbo et al., 2020