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Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

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Similarly, TME-responsive nanoplatforms utilize stimuli like hypoxia, redox imbalance, and enzymatic activity to achieve precise drug release [78]

G6PD deficiency which reduces NADPH production phenocopies GSR impairment for exactly this reason: less NADPH means less GSR-driven GSSG reduction, less available GSH, and more oxidative stress under equivalent ROS production