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606 By activating autophagy and inhibiting ferroptosis, rapamycin reduces the loss of dopamine neurons in the substantia nigra and improves behavioral symptoms in PD model mice, suggesting that the mutual regulation of ferroptosis and autophagy may provide therapeutic targets for drug therapy of PD

PMID: 35677226

Gahete 1,2,3,4 , (1)Maimnides Institute of Biomedical Research of Crdoba (IMIBIC), 14004-Crdoba, Spain., (2)Department of Cell Biology, Physiology and Immunology, University of Crdoba, 14004-Crdoba, Spain., (3)Reina Sofa University Hospital (HURS), 14004-Crdoba, Spain., (4)Ciber Pathophysiology of Obesity and Nutrition (CIBERobn), Crdoba, Spain, (5)Department of Hepatology and Liver Transplantation, Reina Sofa University Hospital, 14004- Crdoba, Spain., (6)Ciber Hepatic and Digestive Diseases (CIBERehd), Crdoba, Spain Background: Hepatocellular carcinoma (HCC) genetic and transcriptomic signatures have been widely described

Cellular signalling

ER proteostasis and ER-unfolded protein response (UPR) capacity are reduced under ER reductive stress, thereby promoting senescence