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While protein sources like meat and fish contain every amino acid, they arent high in the types found in bone broth

Inflammatory factors stimulate increased brain microvascular permeability, such as IL-1, TNF-, and IL-6

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Their investigation of a transgenic mouse model (Gpx5-/-) revealed that oxidative DNA damage does not disrupt the organization of chromosomes but significantly alters specific 3D nuclear parameters

Its pathophysiology involves multiple interconnected mechanisms, including monoaminergic neurotransmitter depletion, impaired neurotrophic signaling, neuroinflammation accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and glutamate-induced excitotoxicity (Medeir et al., 2020)