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Initially, activated M1 microglia drive the inflammatory response by secreting pro-inflammatory cytokines, which contribute to extracellular matrix degradation, disruption of cell integrity, and damage to the BBB [43]

Tryptophan deprivation results in diminished proteosynthesis and decreased activation of the rapamycin pathway, perhaps contributing to polyneuromyopathy [71]

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In Asian populations, such as this family of sisters, the HFE mutation is rarely detected, making awareness of FD in patients with features of genetic iron overload important