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This process, including fission and fusion, is known as mitochondrial dynamics, which reflects the quality of mitochondria ( Mfn2 gene knockout in the mouse brain not only results in mitochondrial swelling, fragmentation, and structural disruption of mitochondrial cristae in hypothalamic and cortical neurons but also causes significant downregulation of ETC complexes (98100)

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Importantly, patients should continue to be assessed for seizures, scoliosis, lung infection, and other features of RTT that present differently in each patient

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Moreover, patients who continuously took Pinus radiata bark extract and vitamin C combination for 12 months had more than a 50% reduction in the frequency and severity of headaches (92)