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Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes

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This observation supports the first interpretation, suggesting that the nozzles in cyanobacteria exist as monomeric rings lacking conventional associated proteins or pilotins when fully assembled