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This dosage showed the potential to trigger an elevation in the number of mitochondria and upregulation in the expression of the Ucp2 gene, which has a crucial role in regulating the mitochondrial processes associated with energy balance to prevent excessive weight gain

10.1038/ncb885 118 VasiukovG.NovitskayaT.ZijlstraA.OwensP.YeF.ZhaoZ.et al (2020)

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This group also studied mice with doxorubicin-induced cardiomyopathy and found that ferroptosis played an important role, possibly because doxorubicin upregulates HO-1, releasing free iron and leading to the generation of oxidized lipids in the mitochondrial membrane

The intestinal mucosal injury and associated changes in the intestinal microbiome provide the backdrop for the inflammatory processes