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Toxins, including benzene (a chemical sometimes used in manufacturing and chemical synthesis), pesticides, and arsenic Chemotherapy and radiation therapy for cancer treatment Various infectious diseases, including hepatitis, HIV, and Epstein-Barr virus (a type of herpesvirus) Autoimmune disorders such as lupus and rheumatoid arthritis Pregnancy Certain drugs, including some antibiotics, immunosuppressants, and some nonsteroidal anti-inflammatory drugs (NSAIDs) Fanconi anemia ShwachmanDiamond syndrome Ataxia-pancytopenia syndrome Over time, severe heart issues may develop, such as arrhythmia (irregular heartbeat), angina, enlarged heart, and heart failure

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doi: 10.1074/jbc.M110.133579 64 MurphyMP

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