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10.1128/jvi.00871-09 249 ShoreG

[Tetrahedron, 2007, vol

Oral and topical forms of GSH have shown moderate success in reducing melanin levels with minimal side effects, while intravenous use, though popular, raises significant safety concerns, including risks of anaphylaxis and liver damage

The secondary outcomes were: MELASQoL (Melasma Quality of Life Scale), colorimetry (Dif-L: Difference between Luminosity *L between healthy skin and melasma), GAIS (Global Aesthetic Improvement Scale) by blinded photographic assessment and adverse effects