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In contrast, in DCM, M/M activation in the spinal compression site and emotion-related brain circuits progresses in proportion to compression, suggesting that early therapeutic intervention should be considered as soon as upper limb neurological symptoms emerge, even in the absence of motor impairment

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We therefore measured the BA content in liver by LC-MS/MS analysis and found that BA composition was altered in Insr P1195L/ +/HFD liver (Fig

Although the introduction of isotope labeling has partially alleviated the limitation of mass spectrometry being restricted to specific bacterial species, it has not fundamentally overcome the techniques inherent constraints [18, 19]

It is unsafe in patients with preexisting renal impairment