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185 RANKL is produced both as a transmembrane protein and in a soluble form but the membrane-bound form appears to be responsible for the majority of osteoclast formation under normal conditions whereas the soluble form was found to promote cancer cell metastasis to bone in mouse models

doi: 10.1111/myc.12758 389 ShakibPAliASMJavanmardEMardanshahOMohagheghMAZivdariMet al

However, due to the complexity of polysaccharide structure and the bottleneck of separation technology, research on the purification process, fine structure, biological activity, and mechanism of action of COPs is still at an exploration stage

Results also evidenced that kava extract and kavalactones possess a week induction on P-glycoprotein ATPase activity

Xue C, Chen K, Gao Z, Bao T, Dong L, Zhao L, et al