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The changes in the activities of glutamine synthase and xanthine oxidase led to the overproduction of ROS, which in turn caused oxidative DNA damage and activated the p53 signaling pathway to induce apoptosis (Wang et al., 2021a)

Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response

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For instance, beyond their DHAR activity, fungal and bacterial GHRs characterized so far efficiently reduce glutathionylated (chlorinated) (hydro)quinones with k cat around 10 3 s 1 and k cat / K m up to 10 6 M 1 .s 1 (Table 5) (Huang et al., 2008