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Single-cell multi-omics analysis further identified key resistance-driving events, such as reduced chromatin accessibility of the dCK promoter (confirmed by scATAC-seq) (Fang et al., 2024) and cell cycle deregulation caused by CDKN2A loss (Buj et al., 2025)

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doi: 10.1093/qjmed/hcs085 343 BurtonARRahmanKKadotaYLloydAVollmer-ConnaU

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Dimethyl diacetyl cystinate shifts the intracellular redox balance toward the oxidized state by increasing intracellular oxidized glutathione (GSSG) content, competitively blocking the binding of activated NF-B to DNA, thereby inhibiting the production of inflammatory factors such as IL-1