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These channels promote intercellular communication by permitting the release of gliotransmitters such as adenosine triphosphate (ATP) and glutamate, as well as calcium ions (Ca 2+ ), which are essential in neuroinflammatory mechanisms [11]

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Apart from exogenous sources, ROS and RNS are also produced endogenously via partial reduction of molecular oxygen (O 2 ) in the respiratory chain within the mitochondria [18]

(ISBN: 978-0-07-149618-6) Keywords Cocaine Toxicology Source: Drug of abuse Mechanism of Action: CNS stimulant blocks the reuptake of catecholamines: dopamine, norepinephrine & serotonin (DAT, NET & SERT transporters) Na and K channel blocker (at slightly higher doses than those blocking reuptake of catecholamines commonly coadministered with ethanol to create cocaethylene which has a longer half-life (and prolonged high) Symptoms: CNS : Euphoria , which may be followed by anxiety & agitation Psychatric symptoms (including paranoia, psychosis & the sensation of something crawling on the skin or itchy skin) Hyperactivity & Seizures (usually self limiting

Step 2: Preparation The injection area is cleaned, and we review treatment expectations