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Clinical evidence demonstrated that increased ROS production and decreased NO bioavailability were in hypertensive patients [114]

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4.1.16 STUB1 STIP1 homology U-box-containing protein 1 STUB1, also known as C terminus of HSP70-interacting protein (CHIP), is a multifunctional protein with both chaperone activity and U-box-dependent E3 ubiquitin ligase activity (Rosser et al., 2007)