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The appropriate route and dose depend on the clinical scenario

While you can get additional B12 through your diet (see below), it is difficult to monitor the increased levels to see if they are closer to satisfactory

8 One study compared the effectiveness of sublingual B12 with B12 injections for raising levels in patients with vitamin B12 deficiency

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Its small molecule structure makes it a practical orally-administered research tool, setting it apart from the injectable peptides that dominate this research space