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Moreover, cytokines such as TNF- and IL-1, which are elevated in CIRS, can downregulate VEGF expression in some contexts, further impairing angiogenic repair mechanisms

Pro-inflammatory cytokines such as TNF- can bind to corresponding receptors and activate signaling pathways like NF-B and MAPK, which in turn induce the expression of pro-inflammatory factors like IL-1 and IL-6, thereby exacerbating the inflammatory response (Hirano, 2021

Minoxidil is a medication originally developed to treat high blood pressure

Although you may see changes on the scale, they are typically minor and will not have a significant impact on your overall weight