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Efficacy and Safety of Sulforaphane for Treatment of Mild to Moderate Depression in Patients with History of Cardiac Interventions: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Wang M, Kaufman RJ

To evaluate the therapeutic efficacy of LXR inverse agonists in vivo, we used three different dysmetabolic rodent models, including high-fat diet (HFD)-induced obese (DIO) mice, HFD-fed Zucker diabetic fatty (ZDF) rats and HFD-fed SpragueDawley (SD) rats (Extended Data Fig