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HFD and Met and choline-deficient diet (MCD) can mimic human diseases histological and metabolic abnormalities and are commonly used to establish NAFLD mouse models

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The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats

Transgenic murine models for cognition Beyond chemical lesion models (scopolamine, 192-IgG-saporin), cognitive research has an arsenal of genetically modified strains that reproduce specific cognitive phenotypes: Alzheimer models 3xTg-AD (LaFerla): triple transgenic APP Swedish, PS1 M146V, tau P301L

3) Glycaemic and cardiometabolic endpoints in defined populations Some cagrilintide combination studies include participants with type 2 diabetes and report glycaemic endpoints such as HbA1c alongside weight change