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2.3 Dysregulation of mitophagy The accumulation of fragmented and dysfunctional mitochondria resulting from excessive fission imposes a critical burden on the mitophagic clearance system

These factors disrupt the delicate balance between the beneficial and harmful roles of lipids, leading to synaptic damage by impairing neurotransmitter release, synaptic plasticity, and membrane stability ( Table 3 )

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Hu Y, Xu J, Wang J, Wang J, Li Y, Chen W, et al

Willemsen, J