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Whether continuous stimulation of the HPG axis over years produces receptor downregulation or other adaptive changes that reduce efficacy over time is a question that longitudinal observational data is beginning to answer, but no definitive answer exists yet

Although the role of CD44 in the transport activity of xCT has not been validated so far, an interesting implication in iron endocytosis via CD44-bound hyaluronates is proposed (Figure 1)

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Amyloid Deposits and Fibrosis on Left Ventricular Endomyocardial Biopsy Correlate With Extracellular Volume in Cardiac Amyloidosis