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Abstract Oxidative stress (OxS) constitutes a disturbance caused by an imbalance between the generation of free radicals and antioxidant system, which causes damage to biomolecules

Conclusion: This is the first reported sIND trial of Maralixibat for treatment of ARC syndrome

Accordingly, substituting the C-terminal L585 residue of albumin with an amino acid resistant to the enzymatic cleavage by CPA proved challenging without compromising receptor engagement

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They effectively inhibited BCR:ABL1 kinase activity and were bound to BCR:ABL1 in chronic myeloid leukemia (CML) cell lysates and permeabilized cells