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It is often found in earlier medicine research where concentrations tested on animal models are unattainable in the blood circulation of human patients, compromising physiological relevance

The biological activity of these NPs depends largely on their size, surface characteristics, and chemical composition, which influence their reactivity and interactions with biological tissues 29

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First, rats were habituated to the arena (5 min center chamber +8 min entire apparatus)

This condition is characterized by a reduction in testicular antioxidants and hormone levels, causing mitochondrial dysfunction and decreased sperm motility as a result of oxidative stress (116, 117)