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Together with the fact that no clear hints for the need for rescue analgesia could be drawn from the data of the von Frey Filament tests, it is questionable whether the use of a test for skin hyperesthesia is a good choice for evaluating immediate postoperative analgesia

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However, taking into account the short time spans simulated, it can be expected that alkenes can be further modified, leading to the formation of the observed alcohols after OH-addition 44

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2C) [24, 26]