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Description

Ferroptosis is distinguished by unique morphological and chemical attributes

Allosteric regulation of phosphofructokinase-1 is also substantiated by activation by ADP (weakly) and AMP (strongly, which is generated by adenylate kinase from two ADPs to regenerate ATP) and by inhibition by citrate

The combination of UK-5099 with JMF4073 depleted dTTP and dCTP pools to achieve both in vitro and in vivo therapeutic effects

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That most of this protection was immune-mediated could be demonstrated by the observation that failure to vaccinate the mice against DNP abrogated the protection (purple lines)