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In this group, CCL3 and IL1B were the most responsive genes, at the transcriptional level, to B12, but no differences were observed in the intracellular levels of the respective proteins ( Figures 3E, F )

doi: 10.1038/sj.bjc.6604965

Figure 4 3.3 Circulatory levels of Sucrosomial B12 vs

Although PKR is not a canonical pattern recognition receptor and does not directly induce antiviral or pro-inflammatory cytokine cascades, it suppresses the translation of both viral and host mRNAs, leading to global translation inhibition