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However, silencing of either STEAP1 or DMT1 did not improve their tolerance to Cu any further (Supplementary Fig

Immune-specific Copper is a structural and functional component of an important antioxidant enzyme called superoxide dismutase that protects immune cells from oxidative damage

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In a randomized clinical trial, the antioxidant astaxanthin, in combination with collagen peptides, improved facial skin elasticity and hydration and reduced matrix metalloproteinase expression while increasing endogenous collagen expression 54 , suggesting enhanced collagen homeostasis

Most patients notice fatigue improvement within days to weeks of starting treatment, though neurological recovery may take 6-12 months