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TRPM2 was shown to be activated by hypoxia-induced ADP-ribose and oxidative stress, common events in DR pathogenesis, and its blockage restored pro-inflammatory cytokines (TNF- and IL-1) and ROS levels (zkaya et al., 2021)

Originally developed in Russia by Professor Vladimir Khavinson, the substance was designed to mimic the effect of a naturally occurring peptide in the pineal glanda small formation in the brain that helps regulate sleep patterns by producing melatonin

Ibuprofen, an NSAID, reduces inflammation and pain, while cyclobenzaprine relaxes muscles

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