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After the model was expanded to include GS-H 2 Q adduct formation as a function of its reduction potential, it was then combined with the Reed glutathione model 21 in order to simulate how the quinone redox-metabolism of doxorubicin influenced the glutathione metabolism

2 Preclinical and mechanistic evidence of TCM active constituents in PD We conducted a narrative appraisal of study-design features as reported in the included articles, noting the presence or absence of randomization, blinding, allocation concealment, sample-size justification, outcome-assessor masking, selective reporting, and funding or conflicts of interest

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