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(Science, 295, pg 2103 (2002)) Fig: Surface Plasmon Resonance animation: SPR evanaescent wave This technique can distinguish fast and slow binding/dissociation of ligands (as reflected in on and off rates) and be used to determine Kd values (through measurement of the amount of ligand bond at a given total concentration of ligand or more indirectly through determination of both kon and koff

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