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10.1507/endocrj.EJ21-0480 123 XueZ.LiJ.FengJ.HanH.ZhaoJ.ZhangJ.et al (2021)

It is generally recommended to start with less frequent application, such as every other night or every third night, and gradually increasing to nightly use as tolerated

Neuronal-astrocyte metabolic association is essential for GSH synthesis, and it has been conducted on co-cultured astrocytes and neurons in which the presence of astrocytes leads to elevated GSH levels in neurons