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(3) the more effective combination partner, phenformin, has been linked to increased lactic acidosis in patients 80 , which is to be avoided in patients with CRC

[link] Perbal B, Lau L, Lyons K, Kubota S, Yeger H, Fisher G., "Report on the 8th International Workshop on the CCN Family of Genes", J Cell Commun Signal 10: 77-86 (2016)

Furthermore, combining AP1 with anti-programmed cell death protein 1 (anti-PD-1) therapy was shown to significantly inhibit tumor growth and restore antitumor immunity in a previous study (54)

While that 5% uptick was a selling point for some of our testers, it is the upper limit of concentrations that dermatologists recommended to us