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Discussion Leukaemic blasts freely infiltrate the CNS without undergoing subclonal selection 46

It has been estimated that an onset delay of 5 years would reduce the number of diagnosed patients by upwards of 50% [51,52]

Furthermore, K + activates ATPase in the TCA cycle and provides energy for the Na + -K + pump to maintain normal cellular membrane function

Kavanaugh A, Gladman DD, Edwards CJ, Schett G, Guerette B, Delev N, Teng L, Paris M, Mease PJ (2019) Long-term experience with apremilast in patients with psoriatic arthritis: 5-year results from a PALACE 13 pooled analysis