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Hernandez-Castro I, et al

when 4-OHE2 is not cleared by COMT or SULT1A1, it oxidizes to quinones that GSTM1/GSTT1 must conjugate

Proton-pump Inhibitors I didnt know it at the time, but the first sign of this depletion was my toes suffering a painful burning sensation that slowed me down during the 2017 Wildcat 100 mile ultra