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A recurring thread is angiogenesis the growth of new blood vessels alongside cell-migration signalling

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A summary of the in vivo models comprehensive of the main advantages and disadvantages and the principal application in CF research is reported in Supplementary Table S1

Lastly, a wide range of soluble factors [e.g., BDNF and chemokine (C-X-C motif) ligand 1 (CXCL1)] released by astrocytes can have myriad effects on myelination, as found in rodents (Tsai et al., 2002

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