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Consistently, a different RCT including 59 patients with mildmoderate ED of mixed etiology demonstrated that a daily treatment with 3 g l-ARG plus 50 mg of the PDE5i sildenafil, administered for 8 weeks, induced a more significant improvement in IIEF-5, compared to sildenafil as single compound [17]

Herrmann JM, Riemer J

Congenital NEMO Alteration at Position 223 causes Ectodermal Dysplasia and Immunodeficiency with Normogammaglobulinemia

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