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Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF--prolyl-4-hydroxylases

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The following dosage recommendations apply, unless otherwise prescribed: At the beginning of treatment, 1 vial of VITAMIN C DEPOT-ROTEXMEDICA (equivalent to 1000 g hydroxocobalamin acetate) is administered twice a week for the first few weeks after diagnosis

0.5 mg/0.1 mL saline/each eye) in a 4-week study permits a very simple and effective protocol, fundoscopy, behavior presentation, tonometry, and histology, to show timely progression of rapid retinal ischemia in rats [13]

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