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The earliest study was a phase 3 REGARD trial (73) conducted in 2009, which involved 355 patients with GC or gastroesophageal junction adenocarcinoma who underwent first-line platinum- or fluoropyrimidine-containing chemotherapy

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Fifteen minutes later, an additional one spray (0.5 mg) of dihydroergotamine mesylate nasal spray should be administered in each nostril, for a total dosage of four sprays (2 mg) of dihydroergotamine mesylate nasal spray

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