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the antibody derivatives include antibodies that have been modified, e.g., by glycosylation, acetylation, pegylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to a cellular ligand or other protein, etc

This can sometimes lead to what's known as a Herxheimer reaction, or a 'healing crisis.' As toxins are mobilized from tissues and flushed out of the body, they can cause temporary symptoms like headaches, fatigue, skin rashes, andyou guessed itdigestive upset

Ferreira SH and Nakamura MI (1979) Prostaglandin hyperalgesia, a cAMP/2+ dependent process

Progress often stalls because the underlying drivers have not been adequately resolved

Otherwise, try not to panic