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Graphical Abstract Access this article Similar content being viewed by others Abbreviations CBD: Cannabidiol THC: Tetrahydrocannabinol ECS: Endocannabinoid system FDA: Food and Drug Administration PD: Parkinsons disease AD: Alzheimer's disease HD: Huntingtons disease MAPK: Mitogen-activated protein kinase PKA: Protein kinase A CINV: Chemotherapy-induced nausea and vomiting IFN-: Interferon gamma TNF-: Tumor necrosis factor alpha CBRs: Cannabinoid receptor OR: Opioid receptors GPRs: G-protein coupled receptor FAAH: Fatty acid amide hydrolase 5-HT 1A : 5-Hydroxytryptamine receptor 1A GABA A : -Aminobutyric acid receptor PPAR-: Peroxisome proliferator-activated receptor TRPV: Transient receptor potential cation channel subfamily V References Earleywine M (2002) Understanding marijuana: a new look at the scientific evidence