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Experimental investigations have demonstrated that S-23 possesses a high-affinity interaction profile at the androgen receptor, making it useful for comparative studies involving receptor selectivity, ligand binding characteristics, and structure-activity relationships among non-steroidal androgen receptor modulators

Research progressed with the contribution of Ramn y Cajal, who developed a method revealing additional cell types beyond neurons and astrocytes, which he termed the third element [37]

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