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Sources & References FDA PCAC Meeting Announcement (July 23-24, 2026) PBS: FDA to Weigh Easing Limits on Peptides Favored by RFK Jr

What we do not know Several questions remain unanswered: Does prolonged amylin receptor agonism produce any adaptive changes in receptor expression or sensitivity that could alter efficacy or safety over years

Cytoprotection by prostaglandins

Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring