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Mortality in sickle cell disease

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DNA methylation dependent silencing of the human glutamate transporter EAAT2 gene in glial cells

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Last, developmental studies investigating the effects of chronic stress converge on evidence that stress may impact brain maturational trajectory and rate, especially accelerating the maturation of affective-related circuits [86, 87], which may both represent an advantage in adverse conditions but may also limit plasticity and raise vulnerability to subsequent anxiety and affective disorders