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In the CNS, ammonia is theorized to cause inflammation, oxidative injury, astrocyte swelling, increased NMDA activity, and osmotic stress which can all lead to brain injury and cerebral edema

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Axonal transport of endogenous nerve growth factor (NGF) and NGF receptor in experimental diabetic neuropathy

The exact duration depends on the package size and recommended daily serving

Smaller trials in those at high risk of atherosclerosis have reported no benefit of vitamin K 2 supplementation on progression of arterial calcification