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For this reason, it is generally recommended that the therapeutic regimen be kept as simple as possible, since the risk of adverse effects is lower when one or two agents are given at higher doses as compared to a multiple-drug regimen using lower doses

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From a vascular perspective, exercise protects the BBB and basement membrane integrity by downregulating matrix metalloproteinase-9 (MMP-9) and upregulating tissue inhibitors of metalloproteinases (TIMPs) [295] (Fig

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