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Reduced ALDH enzymatic activity causes acetaldehyde to accumulate in the bloodstream after alcohol consumption, triggering symptoms such as nausea, tachycardia, facial flushing, and headache (45)

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By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models